2007年4月～2026年3月に42件の臨床研究を実施しました。　
※本部門責任者が研究責任者として実施したもののみ

» 臨床研究一覧はこちら

• » F Higashikawa*, M Noda, T Awaya, K Nomura, H Oku, M Sugiyama.
  Improvement of constipation and liver function by plant-derived lactic acid bacteria: A double-blind, randomized trial.
  Nutrition. 2010, Apr;26(4):367-74. (Citations: 159, FWCI: 1.88, Q1)
  ※ "The 14th John M. Kinney Award for General Nutrition,” in Sep, 2011
  ※ In the top 10% most cited publications worldwide (SciVal 2025).
  
• » X Zhao, F Higashikawa, M Noda, Y Kawamura, Y Matoba, T Kumagai, M Sugiyama.
  The Obesity and Fatty Liver Are Reduced by Plant-Derived Pediococcus pentosaceus LP28 in High Fat Diet-Induced Obese Mice. PLoS One. 2012, 7(2):e30696. (Citations: 129, FWCI: 1.15, Q1)
  ※ FH supervised the study design, data analysis, and manuscript preparation as part of the student’s PhD thesis project.
  ※ In the top 10% most cited publications worldwide (SciVal 2025).
  
• » F Higashikawa, M Noda, T Awaya, T Tanaka, M Sugiyama.
  5-aminolevulinic acid, a precursor of heme, reduces both fasting and postprandial glucose levels in mildly hyperglycemic subjects.Nutrition. 2013, Jul-Aug;29(7-8):1030-6. (Citations: 67, FWCI: 1.10, Q1)
  
• » F Higashikawa, M Noda, T Awaya, N Danshiitsoodol, Y Matoba, T Kumagai, M Sugiyama.
  Antiobesity effect of Pediococcus pentosaceus LP28 on overweight subjects: a randomized, double-blind, placebo-controlled clinical trial.Eur J Clin Nutr. 2016, May;70(5):582-7. (Citations: 143, FWCI: 2.35, Q1)
  ※ In the top 10% most cited publications worldwide (SciVal 2025).

• » F Higashikawa*, M Noda, T Awaya, M Ushijima, M Sugiyama.
  Reduction of serum lipids by the intake of the extract of garlic fermented with Monascus pilosus: A randomized, double-blind, placebo-controlled clinical trial. Clin Nutr. 2012, Apr;31(2):261-6. (Citations: 42, Q1)
  ※ In the top 10% journals by CiteScore (SciVal 2025).
  
• » Y Sano, A Kandori, K Shima, Y Yamaguchi, T Tsuji, M Noda, F Higashikawa, M Yokoe, S Sakoda.
  Quantifying Parkinson’s disease finger-tapping severity by extracting and synthesizing finger motion properties. Med Biol Eng Comput. 2016, Jun;54(6):953-65. (Citations: 56, Q2)
  
• » F Higashikawa, K Kanno, A Ogata, M Sugiyama.
  Reduction of fatigue and anger-hostility by the oral administration of 5-aminolevulinic acid phosphate: a randomized, double-blind, placebo-controlled, parallel study. Sci Rep. 2020, Sep 29;10(1):16004. (Citations: 29, Q1)
  ※ In the top 10% journals by CiteScore (SciVal 2025).

• » Y Nakaniida, F Higashikawa, K Tokumo, Y Yuasa, H Onoe, N Okada, S Nakakura, R Asaoka, Y Kiuchi.
  Effect of Ocular Dominance on Ocular Blood Flow Parameters. Cureus. 2023, Oct 4;15(10):e46500. (Citations: 2)
  
• » F Higashikawa*, Y Nakaniida, H Li, L Liang, K Kanno, K Ogawa-Ochiai, Y Kiuchi.
  Beneficial Effects of Ginger Extract on Eye Fatigue and Shoulder Stiffness: A Randomized, Double-Blind, and Placebo-Controlled Parallel Study. Nutrients. 2024, Aug 15;16(16):2715. (Citations: 4, Q1)
  
• » T Ishino, K Nakagawa, F Higashikawa, S Hirokane, R Fujita, C Ishikawa, T Kawasumi, K Takemoto, T Oda, M Nishida, Y Horibe, N Chikuie, T Taruya, T Hamamoto, T Ueda, L Yuge, S Takeno.
  Intelligibility Sound Therapy Enhances the Ability of Speech-in-Noise Perception and Pre-Perceptual Neurophysiological Response. Biology. 2024, Dec 6;13(12):1021. (Q1)
  ※ In the top 10% journals by CiteScore (SciVal 2025).
  
• » F Higashikawa*, H Ito, T Tanaka.
  Safety of Oral Administration of 5-Aminolevulinic Acid Phosphate Combined with Ferrous Iron in Healthy Subjects: An Open-Label Trial. Sci Pharm. 2025, 93(1), 5. (Q3)
  
• » T Iida, U Ota, K Takahashi, M Ishizuka, F Higashikawa*.
  Temporal transition in urine and plasma porphyrin levels following 5-aminolevulinic acid administration in healthy adults. Photodiagnosis Photodyn Ther. 2025, Nov 23;56:105290. (Citations: 2, Q2)
  
• » S Ogata, N Uda, K Miura, U Enkhbaatar, N Yamasaki, N Hosomi, A Mori, R Hasebe, N Matsuda, F Higashikawa, M Gamboa, S Nakajima, N Kitamura, M Gotoh, S Sekizawa, O Kaminuma.
  Matcha alleviates sneezing response in a murine model of allergic rhinitis. npj Science of Food. 2026 Mar 5. (Q1)

• » F Higashikawa, LJ Chang.
  Kinetic analyses of stability of simple and complex retroviral vectors. Virology. 2001, 280(1): 124-31. (Citations: 251, FWCI: 1.64, Q1)
  ※ In the top 10% most cited publications worldwide (SciVal 2025).
  
• » F Higashikawa, T Murakami, T Kaneda, A Kato, M Takano.
  Dose‐dependent intestinal and hepatic first‐pass metabolism of midazolam, a cytochrome P450 3A substrate with differently modulated enzyme activity in rats. J. Pharm. Pharmacol. 1999, 51(1): 67-72. (Citations: 55, FWCI: 2.91, Q1)
  
• » F Higashikawa, T Murakami, T Kaneda, M Takano.
  In‐vivo and In‐vitro Metabolic Clearance of Midazolam, a Cytochrome P450 3A Substrate, by the Liver under Normal and Increased Enzyme Activity in Rats. J. Pharm. Pharmacol. 1999, 51(4): 405-10. (Citations: 31, FWCI: 2.03, Q1)
  
• » Y Yokosaki, K Tanaka, F Higashikawa, K Yamashita, A Eboshida.
  Distinct structural requirements for binding of the integrins αvβ6, αvβ3, αvβ5, α5β1 and α9β1 to osteopontin. Matrix Biol. 2005, 24(6):418-427. (Citations: 214, FWCI: 1.21, Q2)
  ※ In the top 10% most cited publications worldwide (SciVal 2025).
  
• » N Nishimichi, F Higashikawa, HH Kinoh, Y Tateishi, H Matsuda, Y Yokosaki.
  Polymeric osteopontin employs integrin α9β1 as a receptor and attracts neutrophils by presenting a de novo binding site. J Biol Chem. 2009 May 29;284(22):14769-76.(Citations: 68, FWCI: 1.50, Q1)
  ※ The first and second authors contributed equally to this work.
  
• » F Higashikawa, A Eboshida, Y Yokosaki.
  Enhanced biological activity of polymeric osteopontin. FEBS Lett. 2007 Jul 10;581(14):2697-701. (Citations: 62, FWCI: 1.01, Q1)